Authors:
Giovanna BruniC.S.G.I., Department of Chemistry, Section of Physical Chemistry, University of Pavia, Viale Taramelli 16, 27100, Pavia, Italy

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Franco SartorAptuit Srl, Via Fleming 4, 37135, Verona, Italy

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Vittorio BerbenniC.S.G.I., Department of Chemistry, Section of Physical Chemistry, University of Pavia, Viale Taramelli 16, 27100, Pavia, Italy

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Chiara MilaneseC.S.G.I., Department of Chemistry, Section of Physical Chemistry, University of Pavia, Viale Taramelli 16, 27100, Pavia, Italy

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Mariarosa MaiettaC.S.G.I., Department of Chemistry, Section of Physical Chemistry, University of Pavia, Viale Taramelli 16, 27100, Pavia, Italy

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Dionigio FranchiGlaxoSmithKline SpA, Via Fleming 2, 37135, Verona, Italy

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Amedeo MariniC.S.G.I., Department of Chemistry, Section of Physical Chemistry, University of Pavia, Viale Taramelli 16, 27100, Pavia, Italy

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Abstract

In this study, we present a full thermal characterization of antidepressant paroxetine and summarize the results for another drug which treats depression: GW597599B. The main aim is to analyze how the thermodynamic and structural properties of these compounds are modified when the two drugs are mixed in the solid state. We begin by putting into evidence how dehydration and melting concur in shaping the calorimetric curves of paroxetine under different experimental conditions. Equipped with this knowledge, we are able to interpret the thermal response of the physical mixtures paroxetine:GW597599B, in terms of partial eutectic formation and simple superposition of contribution from the two compounds.

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  • 9. Marini, A, Berbenni, V, Bruni, G, Cofrancesco, P, Giordano, F, Villa, M. Physico-chemical characterization of drugs and drug forms in the solid state. Curr Med Chem Anti Infect Agents. 2003;2:303321. .

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  • 11. Marini, A, Berbenni, V, Bruni, G, Maggioni, A, Cofrancesco, P, Sinistri, C, Orlandi, A, Villa, M. Solid state characterization of a novel chemotherapeutic drug. J Pharm Sci. 2003;92:577584. .

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  • 12. Marini, A, Berbenni, V, Bruni, G, Cofrancesco, P, Margheritis, C, Orlandi, A, Villa, M. Hydration, stability and phase transformations of a new antitumor drug. J Pharm Sci. 2004;93:22222231. .

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  • 13. Bruni, G, Berbenni, V, Milanese, C, Girella, A, Cardini, A, Lanfranconi, S, Marini, A. New modifications of nateglinide. J Pharm Biomed Anal. 2010;51:10541059. .

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  • 19. Bruni, G, Milanese, C, Berbenni, V, Sartor, F, Villa, M, Marini, A. Cristalline and amourphous phases of a new drug. J Therm Anal Calorim. 2010;102:297303. .

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  • 20. Bruni, G, Amici, L, Berbenni, V, Marini, A, Orlandi, A. Drug-excipient compatibility studies: search of interaction indicators. J Therm Anal Calorim. 2002;68:561573. .

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  • 21. Marini, A, Berbenni, V, Moioli, S, Bruni, G, Cofrancesco, P, Margheritis, C, Villa, M. Drug-excipient compatibility studies by physico-chemical techniques: the case of indomethacin. J Therm Anal Calorim. 2003;73:529545. .

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  • 22. Marini, A, Berbenni, V, Pegoretti, M, Bruni, G, Cofrancesco, P, Sinistri, C, Villa, M. Drug-excipient compatibility studies by physico-chemical techniques: the case of atenolol. J Therm Anal Calorim. 2003;73:547561. .

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  • 23. Bruni, G, Berbenni, V, Milanese, C, Girella, A, Marini, A. Drug-excipient compatibility studies in binary and ternary mixtures by physico-chemical techniques. J Therm Anal Calorim. 2010;102:193201. .

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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