Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 108: Issue 3
Evaluating drug delivery of solid dose tablets by isothermal mechanical analysis
Authors:
Visweswararao Badipatla Department of Chemistry, College of Science and Health Professions, Cleveland State University, Cleveland, OH, USA

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Dean Pohlman Department of Chemistry, College of Science and Health Professions, Cleveland State University, Cleveland, OH, USA

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Manik Pavan Maheswaram Department of Chemistry, College of Science and Health Professions, Cleveland State University, Cleveland, OH, USA

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Dhruthiman Mantheni Department of Chemistry, College of Science and Health Professions, Cleveland State University, Cleveland, OH, USA

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Naullage Indika Perera Department of Chemistry, College of Science and Health Professions, Cleveland State University, Cleveland, OH, USA

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Martin Mittleman Department of Chemistry, College of Science and Health Professions, Cleveland State University, Cleveland, OH, USA

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Kenneth Alexander College of Pharmacy Practice, University of Toledo, Toledo, OH, USA

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Alan Riga Department of Chemistry, College of Science and Health Professions, Cleveland State University, Cleveland, OH, USA
College of Pharmacy Practice, University of Toledo, Toledo, OH, USA
Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH, USA

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Pages:
1287–1292
Online Publication Date:
11 Apr 2011
Publication Date:
01 Jun 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-011-1477-x
Keywords:
Isothermal mechanical analysis; Drug disintegration; Drug dissolution; Tablet disintegration
Restricted access

Abstract

The current United States Pharmacopeia (USP) test for the disintegration of drug tablets does not measure initial disintegration times and does not adequately describe tablet disintegration mechanisms. An Isothermal Mechanical Analysis (IsoTMA) method meeting USP specifications has been developed to measure the initial time and rate of drug disintegration. TMA monitors the physical dimension of the formulated drug tablet as a function of time, temperature, applied stress, and pH. TMA can be used to measure the swelling, shrinkage, or disintegration of a formulated tablet in a specified fluid. The focus of this study is to validate an efficient and precise IsoTMA method to measure dimensional stability of solid dose tablets. The precision of the method along with the effect of pH (1–10) and temperature (25–37 °C) on the rate of delivery was determined for nine drugs. Graphical representations of dimensional changes over time were created and compared. Drug delivery in a specific liquid medium was measured by UV analysis for the active pharmaceutical ingredient. An increase in temperature decreased the disintegration time and increased the disintegration rate (mm/min). For the drugs that are studied in this article, pH did not have an appreciable effect on the rate of disintegration.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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