Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 109: Issue 1
Structural and thermal characterization of sodium ibandronate monohydrate
Authors:
Luciana Malpezzi Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Via Mancinelli 7, 20131, Milano, Italy

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Elisabetta Maccaroni Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Via Mancinelli 7, 20131, Milano, Italy

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Giordano Carcano CNR-IENI—Sezione di Lecco, Corso Promessi Sposi 29, 23900, Lecco, Italy

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Gianpiero Ventimiglia Chemessentia srl—Chemo Group, Via Bovio 6, 28100, Novara, Italy

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Pages:
373–379
Online Publication Date:
10 Jun 2011
Publication Date:
01 Jul 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-011-1698-z
Keywords:
Sodium ibandronate; X-ray analysis; Thermal analysis; Structure determination
Restricted access

Abstract

Sodium Ibandronate (NaIb) belongs to the nitrogen-containing bisphosphonates drugs, used as anti-resorptive medications for the treatment of osteoporosis. The crystalline form of NaIb monohydrate was observed to undergo reversible thermal dehydration and rehydration, according to its hygroscopic nature and to the arrangement of the water molecules in the crystal lattice. Dehydration and rehydration were observed and confirmed by variable temperature X-ray diffraction on the basis of the DSC pattern and TG analysis that shows, by heating the sample from 40 to 200 °C, a loss of 5% weight corresponding to a water molecule loss. The water loss causes a phase transition to a more dense phase that can be rehydrated if it is left in a humid environment. The solid state characterization of NaIb monohydrate has been performed by X-ray single crystal diffraction analysis. The NaIb crystallizes as monohydrate salt in the triclinic system, space group P-1, with Z = 2, a = 5.973(1) Å, b = 9.193(1) Å, c = 14.830(2) Å, α = 98.22(1)°, β = 98.97(1)°, γ = 93.74(1)°, V = 792.9(2) Å3. Each anionic group exist as zwitterionic entity with a total charge of −1. In the crystal packing, the octahedral coordination around the Na cations determines a centrosymmetric double chains structure elongated into the [100] direction. The water molecules are located inside the inter-chains cavities.

  • 1. Vega, D, Baggio, R, Garland, MT 1996 Alendronate. Acta Cryst C52:2198–2201.

  • 2. Martin, MB, Grimley, JS, Lewis, JC, Heath, HT, Bailey, BN, Kendrick, H, Yardley, V, Caldera, A, Lira, R, Urbina, JA, Moreno, SNJ, Docampo, R, Croft, SL, Oldfield, E 2001 Bisphosphonates inhibit the growth of Trypanosome brucei, Trypanosome cruzi, Leishmania donovani, Toxoplasma gondii and Plasmodium falciparum. J Med Chem 44:909–916 .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 3. Fleisdch, H 2002 Development of bisphosphonates. Breast Cancer Res 4:30–34 .

  • 4. Vega, D, Baggio, R, Piro, O 1998 Monosodium Olpadronate monohydrate. Acta Cryst C54:324–327.

  • 5. Vega, D, Fernandez, D, Ellena, JA 2002 Disodium Pamidronate. Acta Cryst C58:m77–m80.

  • 6. Fernandez, D, Vega, D, Ellena, JA 2003 Two members of bisphosphonate class of drugs: a zwitterion and a molecular compound. Acta Cryst C59:o289–o292.

    • Search Google Scholar
    • Export Citation

  • 7. Gossman, WL, Wilson, SR, Oldfield, E 2003 Three hydrates of the bisphosphonate risedronate, consisting of one molecular and two ionic structures. Acta Cryst C59:m33–m36.

    • Search Google Scholar
    • Export Citation

  • 8. Stahl, K, Treppendahl, SP, Preikscaht, H, Fischer, E 2005 Sodium 3-ammonio-1-hydroxypropylidene-1,1-bisphosphonate monohydrate. Acta Cryst E61:m132–m134.

    • Search Google Scholar
    • Export Citation

  • 9. Rogers, MJ 2003 New insights into the molecular mechanisms of action of bisphosphonates. Curr Pharm Des 9:2643–2658 .

  • 10. Eiermann U , Junghans B, Knipp B, Sattelkau T. Ibandronate polymorph B. WO2006081962A1.

  • 11. Eiermann U , Junghans B, Knipp B, Sattelkau T. Ibandronate polymorph A. WO2006081963A1.

  • 12. Pulla Reddy M , Usharani V, Venkaiah Chowdary, N. Novel Polymorphic forms of ibandronate. WO2007074475A3.

  • 13. Szterner, P, Legendre, B, Sghaier, M 2010 Thermodynamic properties of polymorphic forms of theophylline. Part I: DSC, TG, X-ray study. J Therm Anal Calorim 99:325–335 .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 14. Malpezzi, L, Fuganti, C, Maccaroni, E, Masciocchi, N, Nardi, A 2010 Thermal and structural characterization of two polymorphs of Atovaquone and of its chloro derivative. J Therm Anal Calorim 102:203–210 .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 15. Drebushchak, VA, Drebushchak, TN, Chukanov, NV, Boldyreva, EV 2008 Transition among five polymorphs of chloropropamide near the melting point. J Therm Anal Calorim 93:243–251.

    • Search Google Scholar
    • Export Citation

  • 16. Lee, EA, Sohn, YT 2008 Crystal forms of a capsaicin derivative analgesic DAA-5018. J Therm Anal Calorim 93:871–874 .

  • 17. Gall R. , Bosies E. Diphosphonate derivatives, pharmaceutical compositions and methods of use. US Patent 4,927,814 (1990).

  • 18. Sheldrick, GM 1996 SADABS University of Göttingen Göttingen.

  • 19. Altomare, A, Burla, MC, Camalli, M, Cascarano, GL, Giacovazzo, C, Guagliardi, A, Moliterni, AGG, Polidori, GP, Spagna, R 1999 SIR97: a new tool for crystal structure determination and refinement. J Appl Cryst 32:115–119 .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 20. Sheldrick, GM 1997 SHELXL-97, program for the refinement of crystal structures University of Göttingen Göttingen.

  • 21. TOPAS-Academic 2007 Version 4.1: Coelho Software TOPAS-Academic Brisbane.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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