Authors:
Xiaoyan Xing China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, People's Republic of China

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Yanling Zhao China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China

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Weijun Kong China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, People's Republic of China

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Yanwei Zhong Viral Hepatitis Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China

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Dan Yan China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China

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Ping Zhang China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China

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Yumei Han China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, People's Republic of China

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Lei Jia China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, People's Republic of China

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Cheng Jin China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China

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Xiaohe Xiao China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People's Republic of China

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Abstract

In this study, microcalorimetry combined with chemometric analysis was used to investigate the effects of angle and nail animal valuable drugs on Bacillus subtilis (B. subtilis) growth. The power–time curves of the growth metabolism of B. subtilis affected by Cornu Cervi Pantotrichum, Cornu Cervi Elaphi, Cornu Saigae Tataricae, cornu caprae hircus, Cornu Bubali, Squama Manis, and Carapax Trionycis were determined using a thermal activity monitor (TAM) air isothermal microcalorimeter, ampoule mode, at 37 °C. By analyzing these curves and some quantitative parameters using principal component analysis, the effects of the seven animal drugs on B. subtilis could be quickly evaluated from the change of the two main parameters, the maximum heat-flow power Pm2 and total heat output Qt: Cornu Saigae Tataricae, cornu caprae hircus, Cornu Bubali, Squama Manis, and Carapax Trionycis inhibited the growth of B. subtilis, while Cornu Cervi Pantotrichum and Cornu Cervi Elaphi promoted the growth of B. subtilis. Further, the result of hierarchical clustering analysis showed that the drugs which promoted the growth of B. subtilis gathered in one cluster, the other drugs which inhibited the growth of B. subtilis gathered in the other cluster. All these illustrated that the internal characteristics of the seven animal drugs were different though they had similar resources and these drugs could be well clustered according the effects of them on B. subtilis growth with the help of chemometric methods. This study provided an useful idea of the combination of microcalorimetry and chemometric analysis for studying the effects of drugs on organisms.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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