Authors:
Xingfeng Li Pharmacy College, Hunan University of Traditional Chinese Medicine, Changsha 410 208, People's Republic of China

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Cheng Jin China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, 100 West 4th Ring Middle Road, Beijing 100 039, People's Republic of China

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Jing He China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, 100 West 4th Ring Middle Road, Beijing 100 039, People's Republic of China

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Jian Zhou China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, 100 West 4th Ring Middle Road, Beijing 100 039, People's Republic of China

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Haitao Wang Department of Pharmacy, 306 Military Hospital, Beijing 100101, People's Republic of China

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Bing Dai Pharmacy College, Hunan University of Traditional Chinese Medicine, Changsha 410 208, People's Republic of China

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Dan Yan China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, 100 West 4th Ring Middle Road, Beijing 100 039, People's Republic of China

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Jiabo Wang China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, 100 West 4th Ring Middle Road, Beijing 100 039, People's Republic of China

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Yanling Zhao China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, 100 West 4th Ring Middle Road, Beijing 100 039, People's Republic of China

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Xiaohe Xiao China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, 100 West 4th Ring Middle Road, Beijing 100 039, People's Republic of China

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Abstract

The antibacterial effect of Curcumin on Staphylococcus aureus growth was evaluated by microcalorimetry. The heat flow power–time curves and nine quantitative parameters of the S. aureus growth were applied to investigate the inhibitory effect with Curcumin. By analyzing these curves and some quantitative parameters using multivariate analytical methods, similarity analysis and principal component analysis, the antibacterial activity of Curcumin on S. aureus could be accurately evaluated from the change of the two main parameters, the second exponential growth rate constant k2 and the maximum heat flow power Pm2. The main two thermal parameters played more important role in the evaluation: at low concentration (0–10.5 μg mL−1), Curcumin hardly influence the growth of S. aureus, while at high concentration (10.5–43.4 μg mL−1) it could notably inhibit the growth. All these illustrated that the antibacterial activity of Curcumin on S. aureus was enhanced with the increase of the concentration of this compound. This study might provide an useful method and idea accurately evaluate the antibacterial effects of Curcumin, which provides some useful methods for evaluate the nature antibacterial agents.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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