Authors:
J. C. May Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drugs and Biologics Office of Biologics Research and Review 8800 Rockville Pike 20892 Bethesda Maryland USA

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R. M. Wheeler Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drugs and Biologics Office of Biologics Research and Review 8800 Rockville Pike 20892 Bethesda Maryland USA

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E. Grim Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drugs and Biologics Office of Biologics Research and Review 8800 Rockville Pike 20892 Bethesda Maryland USA

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Thermogravimetry/mass spectrometry is used to identify TG transitions corresponding to loss of residual moisture in freeze-dried biological products with complex TG curves. While TG weight losses were recorded, ion intensities of mass peaksm/e=18 (water) andm/e=44 (carbon dioxide) were monitored continuously for Typhoid Vaccine U.S.P., Meningococcal Polysaccharide Vaccine Groups A and C Combined and Honey Bee Venom Allergenic Extract. MS ion intensities indicated the difference between evolution of residual moisture and moisture associated with product thermal decomposition. Residual moisture values calculated from TG weight losses indicated by mass spectral data agreed with Karl Fischer moisture data.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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