Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 32: Issue 4
DSC of sun-exposed chloroquine phosphate
Authors:
G. Mulokozi Department of Chemistry and Department of Pharmacology University of Sokoto Nigeria

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I. Edafiogho Department of Chemistry and Department of Pharmacology University of Sokoto Nigeria

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A. M. Mulokozi Department of Chemistry and Department of Pharmacology University of Sokoto Nigeria

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S. Diete-Spiff Department of Chemistry and Department of Pharmacology University of Sokoto Nigeria

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Pages:
1139–1143
Online Publication Date:
22 Jul 2005
Publication Date:
01 Jul 1987
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf01905168
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Pharmaceutical intended for use in the tropics are required to maintain their stability under the most severe storage conditions. Chloroquine phosphate, a common antimalarial formulation, was exposed to the sun of the roof top under the extreme heat of the Saharan climate during the hot and dry season (February to June) at an average day temperature of 43°. The heat of meltingΔH determined by differential scanning calorimetry decreased from 60.1 J/g to 33.2 J/g after exposure for 73 days, corresponding to 49% decomposition. Differential scanning calorimetry is shown by this work to be a rapid and reliable technique for the routine quality control of chloroquine phosphate powders and tablet formulations.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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