Authors:
J. Ginés Universidad de Sevilla Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia c/Profesor García González, s/n. 41012 Sevilla Spain

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M. Arias Universidad de Sevilla Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia c/Profesor García González, s/n. 41012 Sevilla Spain

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A. Rabasco Universidad de Sevilla Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia c/Profesor García González, s/n. 41012 Sevilla Spain

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P. Sánchez-Soto Universidad de Sevilla Instituto de Ciencia de Materiales de Sevilla, Centro mixto Consejo Superior de Investigaciones Científicas P.O. Box 1115 41080 Sevilla Spain

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Abstract  

Thermal analysis (DSC and HSM), and equilibrium solubility determinations were carried out to elucidate the mechanism of interaction at the solid state in the binary system triamterene-D-mannitol. Physical mixtures (5–90% w/w triamterene) and solid dispersions (5 up to 40% w/w triamterene) were prepared and studied. From DSC and HSM results, the thermal changes were associated with the variations in composition of the binary mixture, being more pronounced in the range 20–50% w/w. The binary phase diagram was proposed, although the exact position of the eutectic was uncertain. This is in accordance with a partial dissolution process detected by HSM. A linear increase in the solubility of triamterene with increasing aqueous mannitol concentration was obtained. The thermodynamic parameters of the solution properties were calculated, with an activation energy value of 96.081 kJ/mole. The solubilization increase was associated with complexation processes and hydrogen bonding formation.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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