Authors:
J. Madarász Technical University of Budapest Institute for General and Analytical Chemistry Gellért tér 4 H-1521 Budapest Hungary

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D. Kozma Technical University of Budapest Department of Organic Chemical Technology Müegyetem rkp. 3 H-1521 Budapest Hungary

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G. Pokol Technical University of Budapest Institute for General and Analytical Chemistry Gellért tér 4 H-1521 Budapest Hungary

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M. Ács Technical University of Budapest Institute for General and Analytical Chemistry Gellért tér 4 H-1521 Budapest Hungary

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E. Fogassy Technical University of Budapest Department of Organic Chemical Technology Müegyetem rkp. 3 H-1521 Budapest Hungary

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Abstract  

Chiral drugs are generally resolved through formation of diastereoisomeric salts of different solubility. When the diastereoisomer salts from a eutectic in the solid phase, a good estimate can be made for the efficiency of the resolution (S), through a calculation based on the eutectic composition (xeu). The eutectic composition can be computed from thermal data of a differential scanning calorimetric (DSC) measurement of the diastereoisomeric salts [1]. In this work we investigated the influence of uncertainties of thermal data on the estimation of the efficiency of resolution (S), spreading throughout the calculations involved. Performance of our error-estimating method is demonstrated on 6 diastereoisomer salt pairs. The obtained deviations are close to the deviations of resolution experiments. Thus, it can be concluded that the DSC measurements are useful means in predicting the efficiency of resolutions.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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