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  • 1 Daiichi Pharmaceutical Co., Ltd. Developmental Research Laboratories 1-16-13 Kitakasai, Edogawa-ku 134 Tokyo Japan
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Abstract  

The phase stabilities of three pseudopolymorphs of DN-9693 were studied by using thermogravimetry and differential thermal analysis. The thermal dehydration of DN-9693·2HCl·H2O proceeds by the mechanism of two-dimensional growth of nuclei. The thermal dehydration of 0.5 mol of H2O per mol of DN-9693·2HCl·2H2O, and that of 2 mol of H2O per mol of DN-9693·2HCl·3H2O, proceed by the mechanisms of three-dimensional diffusion and three-dimensional phase boundary reaction, respectively, but the dehydration followed overlaps with the thermal elimination of HCl. The half-lives for the dehydration at 25°C show that DN-9693·2HCl·H2O is the most stable form.

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