Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 45: Issue 4
Thermal study of complex formation of triamterene with β-cyclodextrin by spray-drying and co-grinding
Authors:
J. Ginés Universidad de Sevilla Departmento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, C/Profesor García González s/n 41012 Sevilla Spain

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M. Arias Universidad de Sevilla Departmento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, C/Profesor García González s/n 41012 Sevilla Spain

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C. Novák Technical University of Budapest Institut of General and Analytical Chemistry St. Gellért tér 4 H-1521 Budapest Hungary

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P. Sánchez-Soto Centro Mixto C.S.I.C. Universidad de Sevilla Instituto de Ciencia de Materiales Apdo. 1115 41080 Sevilla Spain

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A. Ruiz-Conde Centro Mixto C.S.I.C. Universidad de Sevilla Instituto de Ciencia de Materiales Apdo. 1115 41080 Sevilla Spain

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E. Morillo C.S.I.C. Instituto de Recursos Naturales y Agrobiología Apdo. 1052 41080 Sevilla Spain

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Pages:
659–666
Online Publication Date:
09 Jan 2007
Publication Date:
01 Oct 1995
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf02548880
Keywords:
β-cyclodextrin; complex formation; DTA; triamterene; X-ray
Restricted access

Abstract  

The formation of crystalline inclusion complex of triamterene with β-cyclodextrin (β-CD) was studied, evaluating the thermal behaviour and dispersion state of this drug in different types of binary systems. Spray-drying and co-grinding (oscillating mill) mixtures of triameterene with β-CD were prepared in 1∶1 molar ratio. The changes of crystalline properties of original (untreated) triamterene, β-CD, and composites obtained by co-grinding and spray-drying were investigated in comparison with those produced in simple physical mixtures. The thermal behaviour of the different samples was investigated using DTA. X-ray diffraction was applied as a complementary technique. The results have been explained by formation of amorphous drug particles on spray-drying samples and co-grinding or alternatively by means of a solid dispersion formation or a combination of these two. A contamination effect by grinding media was also observed as increasing grinding time.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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