The formation of crystalline inclusion complex of triamterene with β-cyclodextrin (β-CD) was studied, evaluating the thermal
behaviour and dispersion state of this drug in different types of binary systems. Spray-drying and co-grinding (oscillating
mill) mixtures of triameterene with β-CD were prepared in 1∶1 molar ratio. The changes of crystalline properties of original
(untreated) triamterene, β-CD, and composites obtained by co-grinding and spray-drying were investigated in comparison with
those produced in simple physical mixtures. The thermal behaviour of the different samples was investigated using DTA. X-ray
diffraction was applied as a complementary technique. The results have been explained by formation of amorphous drug particles
on spray-drying samples and co-grinding or alternatively by means of a solid dispersion formation or a combination of these
two. A contamination effect by grinding media was also observed as increasing grinding time.