Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 48: Issue 3
Comprehensive studies of Tolperisone·HCl-cyclodextrin complexes
Authors:
Cs. Novák Institute of General and Analytical Chemistry Technical University of Budapest Szent Gellért tér 4 H-1521 Budapest

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M. Kata Department of Pharmaceutical Technology Albert Szent-Györgyi Medical University Eötvös út 6 H-6720 Szeged Hungary

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L. Antal Department of Pharmaceutical Technology Albert Szent-Györgyi Medical University Eötvös út 6 H-6720 Szeged Hungary

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Pages:
503–514
Online Publication Date:
02 Aug 2005
Publication Date:
01 Mar 1997
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf01979497
Keywords:
cyclodextrins; IR spectroscopy; thermal analysis; Tolperisone-HCl; X-ray diffraction
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Solid inclusion complexes of TolperisoneHCl with five various cyclodextrins were prepared by kneading and spray drying. The complex formation between the drug and the cyclodextrins were proven using thermoanalytical methods, X-ray diffraction, IR spectroscopy. The results of the solid state investigations were supported by the liquid phase investigations, such solubility and parition constant measurements and stability constant determination. Among all cyclodextrins used the β- and γ-CD-s were found to be the best complexing agents.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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