Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 49: Issue 2
Solubility and glass transition in the system α-D-trehalose/water
Author:
P. Mehl Transfusion and Cryopreservation Research Program, NMRI, NNMC, Bldg 29 8901 Wisconsin Av., 20889-5607 Bethesda, MD USA

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Pages:
817–822
Online Publication Date:
05 Aug 2005
Publication Date:
01 Aug 1997
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf01996765
Keywords:
glass transition; phase diagram; solubility; trehalose; water
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Abstract  

Precipitation of trehalose dihydrate in water is observed at room temperature for trehalose concentrations higher than 47.5%w/w. Direct observations of crystal melting in water and measures of the solution density determine the thermal variations of trehalose saturationS(T) (mM) in water: ln(S(T))=ln(0.1223)-(1330/T) withR2=0.9982. The glass transition (Tg) curve measured by DSC is lower at low concentrations and higher at high concentrations than previously reported.Tg is also measured as a function of the cooling/warming rates. Analysis of specific heat changes atTg and associated activation energy leads to identify a most stable glassy state around the second eutectic concentration.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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