Author:
J. Elder Merck and Co. Inc., WP102-78 Sumneytown Pike, P.O. Box 4, 19486 West Point, PA USA

Search for other papers by J. Elder in
Current site
Google Scholar
PubMed
Close
Restricted access

Abstract  

Procedures for measuring sublimation rates of pharmaceutical compounds by isothermal thermogravimetry are discussed. Experimental data was obtained using the Mettler TA4000 thermogravimetric system. The sublimation rate is measured directly from the mean weight loss per unit time in the linear region of the monitored TG profile at a set isothermal temperature. This data when fitted to the Arrhenius equation yields the sublimation enthalpy. For the benzoic acid reference, the enthalpy so calculated is 99% of the value obtained from direct vacuum TG measurements. Thermal degradation in the solid state or pre-melting can effect a departure from the characteristic linear mass loss-time sublimative profile. Data pertaining to several established Merck drugs is discussed. Examples where loss of residual solvent, onset of thermal degradation and pre-melting phenomena affect the measurement, are presented.

  • Collapse
  • Expand

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2024 7 0 0
Sep 2024 22 0 0
Oct 2024 50 0 0
Nov 2024 18 0 0
Dec 2024 11 0 0
Jan 2025 16 0 0
Feb 2025 15 0 0