Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 49: Issue 2
Application of thermogravimetry in the quality control of mebendazole
Authors:
Rui Macêdo Departamento de Química/CCEN/UFPB, 58059-900 João Pessoa, Paraíba, CEP, Brazil

Search for other papers by Rui Macêdo in
Current site
Google Scholar
PubMed Close
,
Antonio Gouveia de Souza Departamento de Química/CCEN/UFPB, 58059-900 João Pessoa, Paraíba, CEP, Brazil

Search for other papers by Antonio Gouveia de Souza in
Current site
Google Scholar
PubMed Close
,
Ana Miriam Departamento de Química/CCEN/UFPB, 58059-900 João Pessoa, Paraíba, CEP, Brazil

Search for other papers by Ana Miriam in
Current site
Google Scholar
PubMed Close
, and
Carvalho Macêdo Departamento de Química/CCEN/UFPB, 58059-900 João Pessoa, Paraíba, CEP, Brazil

Search for other papers by Carvalho Macêdo in
Current site
Google Scholar
PubMed Close
Pages:
937–941
Online Publication Date:
05 Aug 2005
Publication Date:
01 Aug 1997
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf01996779
Keywords:
kinetics; mebendazole; quality control; technology
Restricted access

Abstract  

A study was made of the thermal behavior of the starting materials, their mixtures and the resulting mebendazole tablets. The thermal curves were obtained with a Shimadzu thermobalance, model TGA-50, using an air flow of 50 mL min−1 and a heating rate of 10°C min−1 in the temperature interval 30–900°C. The reaction constant velocities for the mebendazole salt and tablets were determined isothermally, using the Arrhenius expression. The thermal stability of mebendazole tablets is lower than that of the mebendazole salt, due to the presence of starch and lactose in the composition. Analysis of the data reveals that thermogravimetry is a powerful tool in pharmaceutical technology and quality control.

  • Collapse
  • Expand
Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jun 2024 10 0 0
Jul 2024 6 0 0
Aug 2024 17 1 2
Sep 2024 21 0 0
Oct 2024 48 0 0
Nov 2024 11 0 0
Dec 2024 5 0 0