Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 50: Issue 5-6

Transformation of chloramphenicol palmitate from therapeutically inactive polymorph A to active polymorph B Identification and determination of modification A in modification B by DSC

Authors:
Zs. Csakurda-Harmathy Institute of Inorganic and Analytical Chemistry, L. Eötvös University, P.O. Box 32, 1518 Budapest 112, Hungary

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and
I. Thege Institute of Inorganic and Analytical Chemistry, L. Eötvös University, P.O. Box 32, 1518 Budapest 112, Hungary

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Pages:
867–871
Online Publication Date:
02 Aug 2005
Publication Date:
01 Dec 1997
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf01979216
Keywords:
chloramphenicol palmitate polymorphs; cyclic heat treatment; polymorph impurity
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Abstract  

The bioeffectivity of the therapeutically stable modification A of chloramphenicol palmitate is essentially less than that of the metastable modification B. The literature data indicate that the transformation of modification B to modification A is always monotropic. However, by means of cyclic heat treatment, the stable, inactive modification A has now been successfully transformed to the ‘metastable’, but pharmaceutically effective modification B. For identification and determination of the inactive polymorph A (as impurity) in the active polymorph B, DSC affords rapid and well-reproducible results on small samples. This method may be recommended for inclusion in pharmacopoeias.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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