View More View Less
  • 1 Faculté de Pharmacie Laboratoire de Chimie Générale et Minérale 15, avenue Charles Flahault 34060 Montpellier cedex 2 15, avenue Charles Flahault 34060 Montpellier cedex 2
  • | 2 Centre de Recherche Pierre Fabre Département de Chimie Analytique 17, avenue Jean Moulin 81106 Castres cedex France 17, avenue Jean Moulin 81106 Castres cedex France
Restricted access

Abstract  

The phase diagram of R(+)-S(-) efaroxan hydrochloride (Tfus.(R)=245.10.3C. ΔHfus.(R)=119.63.0 J g-1) shows a racemic compound. The melting temperature and melting enthalpy of the compound are: Tfus.(RS)=247.80.2C and ΔHfus. (RS)=124.62.4 J g-1. A solid ↔ solid transformation takes place at Ttrs.=1801C, ΔHtrs.=15.00.4 J g-1. This transition is observed between 3 and 97% R(+). The stability of the racemic compound already established in a previous study was confirmed by the value of Petterson's coefficient (i=1.19). The two eutectic positions at 20 and 80% R(+) that define the range over which the racemic compound is found, exclude the use of resolution methods by preferential crystallization.

Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

For subscription options, please visit the website of Springer.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jun 2021 0 0 0
Jul 2021 0 0 0
Aug 2021 1 0 0
Sep 2021 2 0 0
Oct 2021 0 0 0
Nov 2021 1 0 0
Dec 2021 0 0 0