Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 54: Issue 2
Investigation of Progesterone Loaded Poly(D,L-Lactide) Microspheres Using TMDSC, SEM and PXRD
Authors:
V. Hill University of London Centre for Materials Science, School of Pharmacy 29-39 Brunswick Square London WC1N 1AX 29-39 Brunswick Square London WC1N 1AX

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N. Passerini Univ. di Bologna Dipartimento di Scienze Farmaceutiche Via S. Donato 19/2 40127 Bologna Italy Via S. Donato 19/2 40127 Bologna Italy

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D. Craig University of London Centre for Materials Science, School of Pharmacy 29-39 Brunswick Square London WC1N 1AX 29-39 Brunswick Square London WC1N 1AX

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M. Vickers Birkbeck College Department of Crystallography Malet Street London WC1E 7HX Malet Street London WC1E 7HX

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J. Anwar University of London Computational Pharmaceutical Sciences, Department of Pharmacy, Kings College Manresa Road London Manresa Road London

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L. Feely Abbott Laboratoires Ltd. International Development Centre Queenborough, Kent ME11 5EL UK Queenborough, Kent ME11 5EL UK

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Pages:
673–685
Online Publication Date:
13 Dec 2004
Publication Date:
01 Nov 1998
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1010167214806
Keywords:
poly(d,l-lactide); progesterone; PXRD; SEM; TMDSC
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Abstract  

Poly(d,l-lactide) microspheres with progesterone loadings of 0, 10, 20, 30 and 50% w/w were manufactured using an interrupted solvent evaporation process. Spherical microspheres with loadings close to the theoretical values were produced. The glass transition of the polymer could be identified by a step change in the heat capacity measured by TMDSC. Progesterone was found to plasticise the glass transition temperature at contents of 20% w/w or less. At a 30% loading, cold crystallisation of progesterone was seen indicating that an amorphous form of the drug was present; these microspheres were found to exhibit a pitted surface. TMDSC of the 50% progesterone samples suggested that most of the drug was present as crystals. This was supported by the SEM and PXRD results.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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