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  • 1 Szent-Györgyi Albert Medical University Department of Pharmaceutical Technology P.O. Box 121 H-6701 Szeged P.O. Box 121 H-6701 Szeged
  • 2 Technical University of Budapest Institute of General and Analytical Chemistry H-1521 Budapest, Szt. Gellért tér 4 Hungary H-1521 Budapest, Szt. Gellért tér 4 Hungary
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Abstract  

Solid formulas obtained between furosemide and two β-cyclodextrin derivatives (HP-β-CD and RAMEB) were prepared by different methods and in various ratios (1:1 and 1:2). The inclusion complex formation between the drug and the β-CDs of 1:1 ratio was evaluated by mean of thermal analysis (DSC, TG and EGD). Supplementary techniques, such as X-ray diffraction, were also applied to interpret the results of the thermal study of physically mixed and kneaded products. Both studies demonstrated the formation of inclusion complexes in all samples except the physical mix samples; formation of true inclusion complexes was then possible only when the components were in melted form. The complexation increased the solubility and the rate of dissolution of the drug. RAMEB was found to be a better complexing agent than HP-β-CD; in both ratios it can be selected as a vehicle in furosemide tablet preparations.