Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 56: Issue 3
DSC Screening of Potential Prochlorperazine-Excipient Interactions in Preformulation Studies
Authors:
M. Brown Rhodes University Department of Chemistry Grahamstown 6140 South Africa

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E. Antunes Rhodes University Department of Chemistry Grahamstown 6140 South Africa

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B. Glass Rhodes University Department of Chemistry Grahamstown 6140 South Africa

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M. Lebete Rhodes University Department of Chemistry Grahamstown 6140 South Africa

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R. Walker Rhodes University Department of Chemistry Grahamstown 6140 South Africa

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Pages:
1317–1322
Online Publication Date:
16 Aug 2006
Publication Date:
01 Nov 1999
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1010150305542
Keywords:
cyclodextrins; drugs; DSC; excipients; prochlorperazine
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Abstract  

Differential scanning calorimetry was used to examine the thermal behaviour of mixtures of the drug prochlorperazine with standard excipients, to assess potential interactions, and of mixtures with cyclodextrins, to investigate inclusion complexation which could increase the photostability of the drug. For most of the excipients (magnesium stearate, stearic acid, Explotab®, Ac-Di-Sol®, Encompress® and Ludipress®, lactose and Starch 1500) disappearance or broadening of the melting endotherm of the drug indicated interactions. Lubritab® was the only 'inert' excipient tested. Mixtures of prochlorperazine and the cyclodextrins gave incomplete inclusion complexation as shown by only partial disappearance of the melting endotherm of the drug.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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