Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 58: Issue 1
Study of Ethyl Cellulose—Benzoic Acid Interactions in Matrices for Controlled Drug Release by DSC
Authors:
R. Singhal Harcourt Butler Technological Institute Department of Plastic Technology Kanpur 208 002 India Kanpur 208 002 India

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A. Nagpal Harcourt Butler Technological Institute Department of Plastic Technology Kanpur 208 002 India Kanpur 208 002 India

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G. Mathur Defence Material Stores Research and Development Establishment Kanpur 208 013 India Kanpur 208 013 India

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Pages:
29–38
Online Publication Date:
03 Nov 2004
Publication Date:
25 Oct 1999
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1010183301617
Keywords:
benzoicacid; controlled release; DSC; ethyl cellulose; FTIR
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Abstract  

The physical state of benzoic acid (BA) and its interaction with ethyl cellulose (EC) were examined in ethyl cellulose—benzoic acid matrices by Differential Scanning Calorimetry (DSC). The glass transition temperature (Tg) of EC of various matrices having BA in solid solution form (upto 27.7%) was reduced. The BA in matrices containing more than 38.9% drug exhibited distinct melting endotherms due to crystalline form. The peak temperatures of these endotherms were lowered and they broadened as the concentration was lowered. The solubility of BA increased at its melting point as compared to ambient temperature. The melting enthalpy of BA, when plotted as a function of its concentration yielded a straight line with intercept of 330 mg g–1 of matrix. This is the solubility of BA in EC at its melting temperature. Fourier Transform Infra Red Spectroscopy (FTIR) investigations confirmed that hydrogen bonding occurred between EC and BA through hydroxyl groups.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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