Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 58: Issue 2
DSC Studies of the Effects of Cisplatin and Transplatin on G-Actin
Authors:
X.-L. Zhou Peking University Institute of Physical Chemistry Beijing 100871 P. R. China Beijing 100871 P. R. China

Search for other papers by X.-L. Zhou in
Current site
Google Scholar
PubMed Close
,
Y. Yang Peking University Institute of Physical Chemistry Beijing 100871 P. R. China Beijing 100871 P. R. China

Search for other papers by Y. Yang in
Current site
Google Scholar
PubMed Close
,
Z.-F. Li Peking University Institute of Physical Chemistry Beijing 100871 P. R. China Beijing 100871 P. R. China

Search for other papers by Z.-F. Li in
Current site
Google Scholar
PubMed Close
,
B.-H. Wang Peking University Institute of Physical Chemistry Beijing 100871 P. R. China Beijing 100871 P. R. China

Search for other papers by B.-H. Wang in
Current site
Google Scholar
PubMed Close
, and
Y.-M. Zhang Peking University Institute of Physical Chemistry Beijing 100871 P. R. China Beijing 100871 P. R. China

Search for other papers by Y.-M. Zhang in
Current site
Google Scholar
PubMed Close
Pages:
243–248
Online Publication Date:
25 Oct 2004
Publication Date:
25 Nov 1999
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1010143910861
Keywords:
actin; cisplatin; DSC; thiol; transplatin
Restricted access

Abstract  

The effects of cisplatin and its trans isomer transplatin on the thermal denaturation of G-actin were studied with a Micro DSC-III differential scanning calorimeter. The denaturation enthalpy of G-actin was found to be 12 J g–1, and the denaturation temperature was 328 K. The thermal denaturation curve showed that increasing cisplatin concentration decreased the enthalpy change. However, after the ratio of cisplatin to G-actin attained 8:1 (mol:mol), the denaturation enthalpy no longer decreased. Transplatin decreased the enthalpy change more rapidly. In contrast with cisplatin, the denaturation peak at 328 K disappeared, and a strong exothermic peak appeared at 341 K when the ratio of transplatin to G-actin was 8:1 (mol:mol). The enthalpy change was 75 J g–1, which is far in excess of the range of weak interactions. This strong exothermic phenomenon probably reflects the agglutination of protein. The effects of cisplatin and transplatin on the number of the free thiol groups of G-actin are discussed.

  • Collapse
  • Expand
Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2024 42 0 0
May 2024 8 0 0
Jun 2024 11 0 0
Jul 2024 25 0 0
Aug 2024 34 0 0
Sep 2024 5 0 0
Oct 2024 0 0 0