Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 59: Issue 3
Application of Thermal Analysis in The Characterization of Anti-hypertensive Drugs
Authors:
R. Macêdo Federal University of Paraíba Pharmaceutical Technology Laboratory Campus 1, Joăo Pessoa Paraíba 59059-900 Brazil Campus 1, Joăo Pessoa Paraíba 59059-900 Brazil

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T. Gomes do Nascimento Federal University of Paraíba Pharmaceutical Technology Laboratory Campus 1, Joăo Pessoa Paraíba 59059-900 Brazil Campus 1, Joăo Pessoa Paraíba 59059-900 Brazil

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C. Soares Aragăo Federal University of Paraíba Pharmaceutical Technology Laboratory Campus 1, Joăo Pessoa Paraíba 59059-900 Brazil Campus 1, Joăo Pessoa Paraíba 59059-900 Brazil

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A. Barreto Gomes Federal University of Paraíba Pharmaceutical Technology Laboratory Campus 1, Joăo Pessoa Paraíba 59059-900 Brazil Campus 1, Joăo Pessoa Paraíba 59059-900 Brazil

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Pages:
657–661
Online Publication Date:
02 Nov 2004
Publication Date:
01 Mar 2000
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1010176931264
Keywords:
anti-hypertensive drugs; quality control; thermal analysis
Restricted access

Abstract  

The present work reports studies of the thermal behaviour of some anti-hypertensive drugs. Their purities were determined by DSC and specialized pharmacopeial methods. The activation energy values suggest the following sequence of satability: nifedipine>propanolol hydrochloride>captoril. Analysis of the DSC data indicated that the degrees of purity of nifedipine, captopril and propanolol hydrochloride were similar to those found by pharmacopeial methods BP 93 and USP 23. The simplicity, speed and low operational costs of thermal analysis justify its application in the quality control of pharmaceutical drugs.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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