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  • 1 University of Bologna Department of Biochemistry 'G. Moruzzi' Via Belmeloro, 8/2 I-40126 Bologna Italy
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Phthalic acid esters, and in particular bis-2-(ethylhexyl) phthalate, are common environmental contaminants with long-term toxic and carcinogenic effects that readily dissolve in lipid substances. DSC measurements of hydrated multilamellar dipalmitoyl phosphatidylcholine liposomes in the presence of different amounts of bis-2-(ethylhexyl) phthalate, dioctyl phthalate, dibutyl phthalate (DBP) and diethyl phthalate (DEP) were considered. The effects on the main transition temperature, ΔH, and the shape and width of the transition were studied. A decrease in Tm, without an accompanying decrease in ΔH,and increases in both the asymmetry and the width of the main transition peak were observed. In some cases, the calorimetric curve showed complex peak structures arising from the coexistence of various aggregates of different sizes. This was particularly evident in the liposomes with DEP and DBP contents ranging from 5.0 to 7.5% m/m. For all the considered model systems, the effects were noticeable even in the presence of small amounts of phthalates; in the presence of greater amounts, the overall structure of the bilayer was in some cases strongly modified, with the appearance of new different phases. Since the function of a membrane-associated protein is dependent on the lipid structure, phthalates could modify the function by modifying the membrane structure.

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  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
per Year
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Founder Akadémiai Kiadó
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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