New approaches to the analysis of differential scanning calorimetry (DSC) data relating to proteins undergoing irreversible
thermal denaturation have been demonstrated. The experimental approaches include obtaining a set of DSC curves at various
scanning rates and protein concentrations, and also reheating experiments. The mathematical methods of analysis include construction
of a linear anamorphosis and simultaneous fitting of a theoretical expression for the dependence of the excess heat capacity
on temperature to a set of experimental DSC curves. Different kinetic models are discussed: the one-step irreversible model,
the model including two consecutive irreversible steps, the Lumry and Eyring model with a fast equilibrating first step, and
the whole kinetic Lumry and Eyring model.