Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 62: Issue 3
Surface Treatment of Dimenhydrinate Crystals
Authors:
J. Bajdik University of Szeged Department of Pharmaceutical Technology Eötvös u. 6 H-6720 Szeged Hungary Eötvös u. 6 H-6720 Szeged Hungary

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K. Pintye-Hódi University of Szeged Department of Pharmaceutical Technology Eötvös u. 6 H-6720 Szeged Hungary Eötvös u. 6 H-6720 Szeged Hungary

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Cs. Novák Budapest University of Technology and Economics and Research Group for Technical Analytical Chemistry of the Hungarian Academy of Sciences Institute of General and Analytical Chemistry Szent Gellért tér 4 H-1111 Budapest Hungary Szent Gellért tér 4 H-1111 Budapest Hungary

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P. Szabó-Révész University of Szeged Department of Pharmaceutical Technology Eötvös u. 6 H-6720 Szeged Hungary Eötvös u. 6 H-6720 Szeged Hungary

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G. Regdon University of Szeged Department of Pharmaceutical Technology Eötvös u. 6 H-6720 Szeged Hungary Eötvös u. 6 H-6720 Szeged Hungary

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I. Erős University of Szeged Department of Pharmaceutical Technology Eötvös u. 6 H-6720 Szeged Hungary Eötvös u. 6 H-6720 Szeged Hungary

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G. Pokol Budapest University of Technology and Economics and Research Group for Technical Analytical Chemistry of the Hungarian Academy of Sciences Institute of General and Analytical Chemistry Szent Gellért tér 4 H-1111 Budapest Hungary Szent Gellért tér 4 H-1111 Budapest Hungary

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Pages:
797–807
Online Publication Date:
18 Aug 2006
Publication Date:
01 Dec 2000
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1012093929296
Keywords:
dimenhydrinate; DSC; film coating; HPMC; thermal conductivity
Restricted access

Abstract  

Dimenhydrinate is a heat-sensitive antihistamine with a low melting point. The heat-sensitive feature is of importance if direct compression is used. Direct measurement of the heat originating in the texture of tablets during compression is very difficult. Thermoanalytical methods were used as indirect methods to describe the changes in material properties at high temperature: differential scanning calorimetry, thermomicroscopy and thermogravimetric analysis. Film coating method is widely used in pharmaceutical technology. A fluidized bed apparatus was applied to coat the crystals. The coating film forming agent was hydroxy-propyl-methylcellulose (HPMC), which is a gastric-soluble polymer. Thermoanalytical measurements reveal that dimenhydrinate crystals are sensitive to heat. Film coating method does not alter the shape of the DSC curve of dimenhydrinate, but increases the melting point. The presence of a macromolecular film reduces the thermal conductivity, because it separates the particles.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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