Authors:
H. Aki Fukuoka University Department of Pharmaceutics, Faculty of Pharmaceutical Sciences 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180 Japan 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180 Japan

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E. Koizumi Fukuoka University Department of Pharmaceutics, Faculty of Pharmaceutical Sciences 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180 Japan 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180 Japan

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Y. Okamoto Fukuoka University Department of Pharmaceutics, Faculty of Pharmaceutical Sciences 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180 Japan 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180 Japan

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M. Yamamoto Fukuoka University Department of Pharmaceutics, Faculty of Pharmaceutical Sciences 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180 Japan 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180 Japan

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Abstract  

The interactions of benzalkonium chloride (BC)with components of stratum corneum, a model system of intercellular lipids in human stratum corneum and homogenized rat stratum corneum were characterized in terms of thermodynamics at pH 7.5 and 37C. BC was strongly bound to cholesterol and cholesterol sulfate with higher affinities (105~106 M-1) than to any other components of the stratum corneum by hydrophobic interaction and ionic interaction, respectively. BC binding to the model system of intercellular lipids significantly decreased only in the absence of cholesterol. It is indicated that cholesterol and its derivatives play an important role in the penetration and/or accumulation of BC in stratum corneum.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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