Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 64: Issue 2
Thermal Stability of Prednisone Drug and Tablets
Authors:
A. de Medeiros Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica Campus I João Pessoa, PB 58059-900 Brazil Campus I João Pessoa, PB 58059-900 Brazil

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N. de Cervantes Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica Campus I João Pessoa, PB 58059-900 Brazil Campus I João Pessoa, PB 58059-900 Brazil

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A. Gomes Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica Campus I João Pessoa, PB 58059-900 Brazil Campus I João Pessoa, PB 58059-900 Brazil

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R. Macêdo
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Pages:
745–750
Online Publication Date:
02 Nov 2004
Publication Date:
01 May 2001
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1011500629494
Keywords:
DSC-photovisual; pharmaceutical equivalence; polymorphism; prednisone
Restricted access

Abstract  

TG and DSC data were used to determine the thermal parameters of prednisone drug and tablets. Two formulations of prednisone 20 mg were analysed in the form of tablets. The TG curves of prednisone drug and tablets A and B displayed six, eight and seven thermal decomposition processes, respectively. Analysis of the DSC data pointed to chemical interactions between prednisone drug and the excipients of tablets A and B, suggested by alterations in the melting temperature of prednisone. The analysis revealed that prednisone drug is more stable than tablets A and B.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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