Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 64: Issue 2
Comparison of Generic Hydrochlorothiazide Formulations by Means of TG and DSC Coupled to a Photovisual System
Authors:
R. Macêdo Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica Campus I João Pessoa, PB 58059-900 Brazil Campus I João Pessoa, PB 58059-900 Brazil

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T. do Nascimento Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica Campus I João Pessoa, PB 58059-900 Brazil Campus I João Pessoa, PB 58059-900 Brazil

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J. Veras Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica Campus I João Pessoa, PB 58059-900 Brazil Campus I João Pessoa, PB 58059-900 Brazil

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Pages:
757–763
Online Publication Date:
02 Nov 2004
Publication Date:
01 May 2001
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1011504730402
Keywords:
formulations; hydrochlorothiazide; thermal analysis
Restricted access

Abstract  

The compatibilities and stabilities of some binary mixtures and generic hydrochlorothiazide formulations were studied by using TG, DSC and a DSC-photovisual system. The kinetic parameters were determined via the Arrhenius equations. Tablet B presented higher compatibility and thermal stability than those of tablets A and C. The photovisual system demonstrated that the decomposition of tablet A occurs before the melting point, due to the Maillard reaction between the hydrochlorothiazide and lactose present in the formulation. The behaviour and rate constants of binary mixtures suggest that lactose can be substituted for microcrystalline cellulose, MC(101), in tablet A. The DSC and TG data revealed different characteristics of compatibility and stability in generic formulations from different manufacturers.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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