Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 67: Issue 2
Compatibility and Stability Studies of Propranolol Hydrochloride Binary Mixtures and Tablets for TG and DSC-photovisual
Authors:
R. Macêdo Universidade Federal da Paraíba, UFPB Laboratório de Tecnologia Farmacêutica, LTF Campus I João Pessoa, PB CEP: 58050-900 Brazil Campus I João Pessoa, PB CEP: 58050-900 Brazil

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T. Gomes do Nascimento Universidade Federal da Paraíba, UFPB Laboratório de Tecnologia Farmacêutica, LTF Campus I João Pessoa, PB CEP: 58050-900 Brazil Campus I João Pessoa, PB CEP: 58050-900 Brazil

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J. Veras Universidade Federal da Paraíba, UFPB Laboratório de Tecnologia Farmacêutica, LTF Campus I João Pessoa, PB CEP: 58050-900 Brazil Campus I João Pessoa, PB CEP: 58050-900 Brazil

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Pages:
483–489
Online Publication Date:
01 Nov 2004
Publication Date:
01 Feb 2002
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1013901332759
Keywords:
binary mixtures; propranolol; tablets; TG and DSC-photovisual
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Abstract  

This study demonstrates the thermalanalysis applications in compatibility and stability studies of the propranolol binary mixture sand tablets A and B. The propranolol binary mixtures were prepared in the laboratory and compared to the fully formulated tablets using the thermogravimetric (TG) and calorimetric(DSC) methods. DSC of binary mixtures showed similar phase transition to propranolol drug. The tablets phase transition decreased and there was no detectable significant interaction in propranolol–lactose mixture and tablets. The DSC-photovisual test revealed an interaction similar to the Maillard reaction. The TG isothermal study showed a difference in the profile between the drug and tablets due excipients quality and problems in manufacture process. The kinetic parameters indicated a lower stability for the tablets than propranolol drug. The thermal techniques thermally differentiated the propranolol preparations demonstrating the importance in the design development of pharmaceuticals solid-dosage form.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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