This study demonstrates the thermalanalysis applications in compatibility and stability studies of the propranolol binary
mixture sand tablets A and B. The propranolol binary mixtures were prepared in the laboratory and compared to the fully formulated
tablets using the thermogravimetric (TG) and calorimetric(DSC) methods. DSC of binary mixtures showed similar phase transition
to propranolol drug. The tablets phase transition decreased and there was no detectable significant interaction in propranolol–lactose
mixture and tablets. The DSC-photovisual test revealed an interaction similar to the Maillard reaction. The TG isothermal
study showed a difference in the profile between the drug and tablets due excipients quality and problems in manufacture process.
The kinetic parameters indicated a lower stability for the tablets than propranolol drug. The thermal techniques thermally
differentiated the propranolol preparations demonstrating the importance in the design development of pharmaceuticals solid-dosage