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  • 1 University Pharmacy Institute of Pharmacy Administration H-1092 Hőgyes E. u. 7–9 Budapest Hungary H-1092 Hőgyes E. u. 7–9 Budapest Hungary
  • | 2 Gedeon Richter Ltd. H-1103 Gyömrői út 19–21 Budapest Hungary H-1103 Gyömrői út 19–21 Budapest Hungary
  • | 3 Pharmaceutical Institute of the Semmelweis University H-1092 Hőgyes E. u. 9 Budapest Hungary H-1092 Hőgyes E. u. 9 Budapest Hungary
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Abstract  

In the course of the formulation of coated dosage forms, the selection of the suitable composition of the coating system is of great importance in respect of the final dosage form. Since the applied coating systems are multicomponent, the possible interactions between the components determine the physico-chemical stability of the formulated dosage form, the drug release process, as well as the formulation parameters. In the present study, the influence of the applied plasticizer, dibutyl sebacate on the enthalpy relaxation of casted Eudragit L 30D films was determined as a function of the plasticizer concentration. The enthalpy relaxation was recorded by DSC during the applied isothermal recovery process of Eudragit films. The obtained results indicate that enthalpy relaxation can be measured by DSC at 20 mass/mass% dibutyl sebacate concentration, which refers to the increased molecular mobility consequently to the effect of the interaction between the polymer and plasticizer.

Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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