Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 68: Issue 2
Sulphamethizole-Cyclodextrin-Hydroxy Propylmethyl Cellulose Multicomponent Complexes
Authors:
B. Pose-Vilarnovo Univ. de Santiago de Compostela Dept. de Farmacia e Tecnoloxía Farmacéutica, Fac. de Farmacia Campus Sur E-15706 Santiago de Compostela Spain

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X2 Rodríguez-Tenreiro Sánchez Univ. de Santiago de Compostela Dept. de Farmacia e Tecnoloxía Farmacéutica, Fac. de Farmacia Campus Sur E-15706 Santiago de Compostela Spain

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M. Pérez-Marcos Univ. de Santiago de Compostela Dept. de Farmacia e Tecnoloxía Farmacéutica, Fac. de Farmacia Campus Sur E-15706 Santiago de Compostela Spain

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J. Torres-Labandeira Univ. de Santiago de Compostela Dept. de Farmacia e Tecnoloxía Farmacéutica, Fac. de Farmacia Campus Sur E-15706 Santiago de Compostela Spain

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Pages:
657–667
Online Publication Date:
03 Nov 2004
Publication Date:
01 May 2002
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1016016525607
Keywords:
β-cyclodextrin; cyclodextrin inclusion complexes; DSC; hydroxypropyl-β-cyclodextrin; hydroxypropylmethyl cellulose; stability constant; X-ray diffractometry
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Abstract  

The effect of cyclodextrin complexation of sulphamethizole (SM) was studied. Two systems were prepared with two cyclodextrin derivatives, β-cyclodextrin (BCD) and hydroxypropyl-β-cyclodextrin (HPBCD): binary complexes and multicomponent systems (cyclodextrins and a hydroxylpropylmethyl cellulose K4M). Inclusion complexes were prepared by freeze-drying and characterized by thermal analysis (DSC) and X-ray diffractometry. The presence of the polymer in the solution increases the effect of cyclodextrins – specially BCD – on the solubility of SM. In solid state, binary inclusion complexes enhance the dissolution behaviour of SM but, from the multi-component complexes, the polymer controls the release of the drug.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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