γ-Induced Thermal Stability And Thermal Studies On Timolol β-Blocker

M. Abou-Sekkina; M. El-Ries; A. Molokhia; N. Rabie; A. Wassel

doi:10.1023/a:1016111126998

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Journal of Thermal Analysis and Calorimetry

Volume/Issue:: Volume 68: Issue 3

γ-Induced Thermal Stability And Thermal Studies On Timolol β-Blocker

Authors: M. Abou-Sekkina¹, M. El-Ries², A. Molokhia², N. Rabie³, and A. Wassel²

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¹ Tanta University Faculty of Science Tanta Egypt Tanta Egypt
² National Organization for Drug Control and Research Giza Egypt Giza Egypt
³ National Institute for Standards Radiation Dept. Giza Egypt Giza Egypt

DOI:: https://doi.org/10.1023/a:1016111126998

Page Count:: 1017–1023

Publication Date:: 01 Jun 2002

Online Publication Date:: 01 Nov 2004

Article Category:: Research Article

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Abstract

Timolol drug, has been investigated by using X-ray diffraction analysis, thermogravimetry (TG), differential thermal analysis (DTA), IR, HPLC and electronic absorption spectra (UV/Vis), before and after exposure to γ-radiation. The interaction ofγ-rays with timolol has been studied. Results obtained indicated high stability towardγ-absorbed dose over the range 5–50 kGy.

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Journal of Thermal Analysis and Calorimetry

Print ISSN:: 1388-6150

Online ISSN:: 1572-8943

Keywords:: β-blocker; HPLC; IR; γ-radiolysis; thermal stability; timolol; UV; X-ray

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