Authors:
Á. Beretzky University of Szeged Department of Pharmaceutical Technology Eötvös str. 6. Szeged H-6720 Hungary Eötvös str. 6. Szeged H-6720 Hungary

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P. Kása University of Szeged Department of Pharmaceutical Technology Eötvös str. 6. Szeged H-6720 Hungary Eötvös str. 6. Szeged H-6720 Hungary

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K. Pintye-Hódi University of Szeged Department of Pharmaceutical Technology Eötvös str. 6. Szeged H-6720 Hungary Eötvös str. 6. Szeged H-6720 Hungary

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J. Bajdik University of Szeged Department of Pharmaceutical Technology Eötvös str. 6. Szeged H-6720 Hungary Eötvös str. 6. Szeged H-6720 Hungary

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P. Szabó-Révész University of Szeged Department of Pharmaceutical Technology Eötvös str. 6. Szeged H-6720 Hungary Eötvös str. 6. Szeged H-6720 Hungary

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I. Erős University of Szeged Department of Pharmaceutical Technology Eötvös str. 6. Szeged H-6720 Hungary Eötvös str. 6. Szeged H-6720 Hungary

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Abstract  

The flowability of needle- or plate-shaped crystals is very poor and the direct compression of these crystals is difficult. Commercial phenylbutazone consists of needle crystals and it has three polymorphs.The aim of this work was to investigate the solid-state thermal stability of phenylbutazone at condition of the pelletization process (40°C; 60 min). The other aim was the preparation of phenylbutazone pellets with centrifugal granulator.Based non the flowability and the other parameters of, the pellets, they are suitable for capsule filling or tabletting. The centrifugal granulation and the conditions were favourable for the preparation of pellets from phenylbutazone in the form of needle crystals.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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