Authors:
A. Agostiano CNR Centro Studi Chimico Fisici sull"Interazione Luce-Materia Via Orabona 4 I-70126 Bari Italy Via Orabona 4 I-70126 Bari Italy

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L. Catucci Università di Bari Dipartimento di Chimica Via Orabona 4 I-70126 Bari Italy Via Orabona 4 I-70126 Bari Italy

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M. Castagnolo Università di Bari Dipartimento di Chimica Via Orabona 4 I-70126 Bari Italy Via Orabona 4 I-70126 Bari Italy

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D. Colangelo Università di Bari Dipartimento di Chimica Via Orabona 4 I-70126 Bari Italy Via Orabona 4 I-70126 Bari Italy

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P. Cosma Università di Bari Dipartimento di Chimica Via Orabona 4 I-70126 Bari Italy Via Orabona 4 I-70126 Bari Italy

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P. Fini CNR Centro Studi Chimico Fisici sull"Interazione Luce-Materia Via Orabona 4 I-70126 Bari Italy Via Orabona 4 I-70126 Bari Italy

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M. Della Monica Università di Bari Dipartimento di Chimica Via Orabona 4 I-70126 Bari Italy Via Orabona 4 I-70126 Bari Italy

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Abstract  

Cyclodextrins (CDs) are widely used as delivery systems of poorly water soluble drugs in pharmacological applications. The delivery system produces an increase of aqueous solubility of the drug and significant modifications in its physico-chemical and pharmacological properties. In this paper we report the results of our study on aqueous solutions of chlorophyll a, a natural pigment useful as sensitizer in the photodynamic therapy, and two CDs: hydroxypropyl- b-cyclodextrin and heptakis(2,6-di-O-methyl)-b-cyclodextrin. The interactions between chlorophyll and CDs and the effect produced by the presence of the CDs on the aggregation of chlorophyll were studied by calorimetric and UV-Vis spectrophotometric measurements respectively.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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