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  • 1 University of Brighton School of Pharmacy and Biomolecular Sciences, Cockcroft Building Lewes Road, Brighton Sussex BN2 4GJ UK Lewes Road, Brighton Sussex BN2 4GJ UK
  • | 2 GlaxoSmithKline Pharmaceuticals, NFSP (North) Technology Development Group Third Avenue Harlow, Essex CM19 5AW UK Third Avenue Harlow, Essex CM19 5AW UK
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Abstract  

This paper discusses the development of novel liquid phase quartz crystal resonant sensor technologies for label free, real-time detection of pharmaceutical applications.New crystal oscillator technologies are introduced alongside crystal mounting and flow cell designs circumventing more traditional approaches to yield greater robustness, reliability and sensitivity. Data for standardised long-term experiments is presented and analysed with respect to reproducibility and stability and comparisons made with surface plasmon resonance.