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  • 1 Syngenta Huddersfield Manufacturing Centre West Yorkshire UK UK
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Abstract  

Initial plant scale trials of the nitrosation of an amino acid revealed a number of issues: _ Much lower yield compared to laboratory scale _ Considerable loss of mass balance _ Large excess of nitrosating agent required for complete reaction _ Highly reactive off-gases produced causing fires in the carbon absorber _ Reaction sensitive to agitation speed _ The by-product produces an impurity in the next process stage which has high human toxicity A kinetic and mechanistic study of the nitrosation reaction, using isothermal power compensation calorimetry and GC/mass spectrometry, has been undertaken in order to understand the above observations and to produce an improved manufacturing process - more robust, higher yielding, reduced effluent volumes and toxicity.

Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)