Authors:
A. SchmidtUniversity of Innsbruck Institute of Pharmacy, Department of Pharmaceutical Technology Innrain 52 A-6020 Innsbruck Austria Innrain 52 A-6020 Innsbruck Austria

Search for other papers by A. Schmidt in
Current site
Google Scholar
PubMed
Close
,
N. SenfterUniversity of Innsbruck Institute of Pharmacy, Department of Pharmaceutical Technology Innrain 52 A-6020 Innsbruck Austria Innrain 52 A-6020 Innsbruck Austria

Search for other papers by N. Senfter in
Current site
Google Scholar
PubMed
Close
, and
U. GriesserUniversity of Innsbruck Institute of Pharmacy, Department of Pharmaceutical Technology Innrain 52 A-6020 Innsbruck Austria Innrain 52 A-6020 Innsbruck Austria

Search for other papers by U. Griesser in
Current site
Google Scholar
PubMed
Close
Restricted access

Abstract  

Crystal polymorphs of pramocaine hydrochloride (PRCNC) and pramocaine (PRCN) free base were produced and characterized by means of thermomicroscopy, differential scanning calorimetry (DSC), FTIR- and FT-Raman-spectroscopy as well as X-ray-powder diffractometry. The relative thermodynamic stabilities of all forms were determined and are represented in semi-schematic energy/temperature diagrams. PRCN, which is a viscous liquid at room temperature and insoluble in water, was found to exist in two different crystal forms with the melting points 23.5C (mod. I) and 12.5C (mod. II). The water-soluble PRCNC crystallizes in three different crystal modifications. Mod. II is the thermodynamically stable form at room temperature and is present in commercial products. This form is obtained by crystallization from solvents and transforms on heating at about 95C into the high temperature form mod. I which melts at 171.0C. Both compounds show conformational polymorphism with forms of low kinetic stability.

  • Collapse
  • Expand
  • Top

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Feb 2022 3 0 0
Mar 2022 3 0 0
Apr 2022 0 0 0
May 2022 2 0 0
Jun 2022 0 0 0
Jul 2022 1 0 0
Aug 2022 0 0 0

Geopolymers

Inorganic polymeric new materials

Author:
J. Davidovits