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  • 1 Université de Rouen Unité de Croissance Cristalline, de Chromatographie et de Modélisation Moléculaire (UC3M), Sciences et Méthodes Séparatives (SMS) UPRES EA 2659, IRCOF rue Tesniére F-76821 Mont Saint-Aignan Cedex France rue Tesniére F-76821 Mont Saint-Aignan Cedex France
  • | 2 Aventis Pharma Process Development 102 route de Noisy F-93235 Romainville Cedex France route de Noisy F-93235 Romainville Cedex France
  • | 3 Université de Rouen Groupe de Physique des Matériaux UMR 6634 F-76801 Saint Etienne du Rouvray Cedex France F-76801 Saint Etienne du Rouvray Cedex France
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Abstract  

Solid-solid transformations between solvates of pharmaceutical compounds are investigated under various conditions. In the case of Roxithromycin, it is shown that starting from single crystals of the acetonitrile solvate, a transformation towards the monohydrate occurs according to a cooperative mechanism. This smooth exchange of solvent probably involves a transport of matter within channels, and the comparison of crystal structures is consistent with the persistence of the main features of the 3D lattice. By contrast, starting from the DMSO solvate of Dexamethasone acetate, the transformation towards the sesquihydrated form, induced by the immersion of the DMSO solvate in water, is fully destructive and reconstructive. This occurs far-from-equilibrium and is therefore controlled by kinetic factors. The existence of an intermediate liquid phase within the particle is postulated to account for the appearance of whisker-like crystals growing first on high-energy sites of the former particle. An extended analysis of these transformations between solvates shows that they could be classified according to rules previously proposed in the case of desolvation mechanisms.

Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)