Thermal and morphological characterization of micronized acetylsalicylic acid powders prepared by rapid expansion of a supercritical solution

R. Bettini; A. Rossi; E. Lavezzini; E. Frigo; I. Pasquali; F. Giordano

doi:10.1023/a:1025417810761

Journal of Thermal Analysis and Calorimetry

Volume/Issue:: Volume 73: Issue 2

Thermal and morphological characterization of micronized acetylsalicylic acid powders prepared by rapid expansion of a supercritical solution

Authors:

R. Bettini

R. Bettini Universitr di Parma Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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A. Rossi

A. Rossi Universitr di Parma Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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E. Lavezzini

E. Lavezzini University of Parma Department of Pharmacy 43100 Parma Italy 43100 Parma Italy

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E. Frigo

E. Frigo Universitr di Parma Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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I. Pasquali

I. Pasquali Universitr di Parma Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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, and

F. Giordano

F. Giordano Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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Pages:: 487–497

Online Publication Date:: 31 Oct 2004

Publication Date:: 01 Aug 2003

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1025417810761

Keywords:: aspirin; micronisation; RESS; solid-state; supercritical CO2

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Abstract

Aim of this work was to investigate the solid-state characteristics of micronized acetylsalicylic acid (ASA), produced by rapid expansion of a supercritical carbon dioxide solution (RESS) and to assess whether a correlation could be found between process parameters and solid-state characteristics. Drug solubility in supercritical CO₂ was first assessed under various pressure and temperature conditions. DSC, FT-IR, PXRD, SEM, laser light scattering and HPLC were used to characterise the solid phases produced by the RESS. The obtained particles were crystalline, with spectroscopical and diffractometrical pattern overlapping those of the starting available product. However, a strong reduction of particle size was obtained, linearly correlated to pressure imposed during the RESS process, while temperature did not seem to have a major effect. Similar influence of pressure was observed on the final melting temperature of the micronized ASA. The application of a mathematical model allowed to conclude that the melting temperature depression of RESS-prepared ASA powders can be attributed to the decrease of particle dimension rather than to the formation of different solid phases or impurities.

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Journal of Thermal Analysis and Calorimetry

Print ISSN:: 1388-6150

Online ISSN:: 1572-8943

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Journal of Thermal Analysis and Calorimetry
Language	English
Size	A4
Year of Foundation	1969
Volumes per Year	1
Issues per Year	24
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	1388-6150 (Print)
ISSN	1588-2926 (Online)