Authors:
F. Giordano Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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A. Rossi Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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I. Pasquali Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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R. Bettini Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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E. Frigo Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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A. Gazzaniga Universitr di Milano Istituto Chimico Farmaceutico Viale Abruzzi 42 20132 Milano Viale Abruzzi 42 20132 Milano

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M. Sangalli Universitr di Milano Istituto Chimico Farmaceutico Viale Abruzzi 42 20132 Milano Italy Viale Abruzzi 42 20132 Milano Italy

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V. Mileo Chiesi Farmaceutici SpA, R&D Analytical Chemistry Department Via Palermo 26/A 43100 Parma Italy Via Palermo 26/A 43100 Parma Italy

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S. Catinella Chiesi Farmaceutici SpA, R&D Analytical Chemistry Department Via Palermo 26/A 43100 Parma Italy Via Palermo 26/A 43100 Parma Italy

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Abstract  

The thermal behaviour of Diclofenac was investigated using Differential Scanning Calorimetry, Hot Stage Microscopy, and Thermogravimetric Analysis. A discrepancy was observed between the melting point values recorded under dynamic flow of either dry nitrogen (180C) or air (160C). By means of High Performance Liquid Chromatography/Mass Spectrometric analyses, it has been possible to ascribe this difference in melting points to the formation of three degradation products as a result of intramolecular cyclization and condensation reactions during the heating process in an oxidative atmosphere.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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