Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 73: Issue 2
Thermal degradation and melting point determination of diclofenac
Authors:
F. Giordano Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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A. Rossi Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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I. Pasquali Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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R. Bettini Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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E. Frigo Universitr di Parma Department of Pharmacy Dipartimento Farmaceutico Viale delle Scienze 27A 43100 Parma Italy Viale delle Scienze 27A 43100 Parma Italy

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A. Gazzaniga Universitr di Milano Istituto Chimico Farmaceutico Viale Abruzzi 42 20132 Milano Viale Abruzzi 42 20132 Milano

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M. Sangalli Universitr di Milano Istituto Chimico Farmaceutico Viale Abruzzi 42 20132 Milano Italy Viale Abruzzi 42 20132 Milano Italy

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V. Mileo Chiesi Farmaceutici SpA, R&D Analytical Chemistry Department Via Palermo 26/A 43100 Parma Italy Via Palermo 26/A 43100 Parma Italy

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S. Catinella Chiesi Farmaceutici SpA, R&D Analytical Chemistry Department Via Palermo 26/A 43100 Parma Italy Via Palermo 26/A 43100 Parma Italy

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Pages:
509–518
Online Publication Date:
31 Oct 2004
Publication Date:
01 Aug 2003
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1025421911670
Keywords:
drug degradation; thermal decomposition; HPLC-MS analysis; oxidative atmosphere; melting point; diclofenac
Restricted access

Abstract  

The thermal behaviour of Diclofenac was investigated using Differential Scanning Calorimetry, Hot Stage Microscopy, and Thermogravimetric Analysis. A discrepancy was observed between the melting point values recorded under dynamic flow of either dry nitrogen (180C) or air (160C). By means of High Performance Liquid Chromatography/Mass Spectrometric analyses, it has been possible to ascribe this difference in melting points to the formation of three degradation products as a result of intramolecular cyclization and condensation reactions during the heating process in an oxidative atmosphere.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Manuscript Submission: HERE

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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