Thermal treatment of torasemide form A resulted in several effects which were divided into five steps. These were investigated and discussed applying TG-MS and TG-FTIR with additional information derived from SEM, hot-stage and FTIR microscopy. The investigated crystal form of torasemide represents a mixed solvate including ethanol and water. Its desolvation, the solid-solid transformation into the anhydrate mod. II and the melting of this anhydrate is elucidated using thermal analysis and microscopic observations (FTIR and hot-stage microscopy). The released and evaporated solvents were determined with coupled techniques. On further heating the structural identification of evolved gases allowed the analysis of the degradation pathway of torasemide up to 340C.
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| Journal of Thermal Analysis and Calorimetry | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1969 |
| Volumes per Year |
1 |
| Issues per Year |
24 |
| Founder | Akadémiai Kiadó |
| Founder's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Publisher | Akadémiai Kiadó Springer Nature Switzerland AG |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 1388-6150 (Print) |
| ISSN | 1588-2926 (Online) |
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