This work exemplifies a general method of studying the drug excipient interactions, with the aim of predicting rapidly and
inexpensively the long term stability of their mixtures. We study the physico-chemical properties of a drug (indomethacin)
in the solid state and in different combinations with several excipients (PVP=polyvinylpyrrolidone, MGST=magnesium stearate,
Avicel©). We compare the properties of pure compounds (untreated, or moisture/temperature conditioned) with those of binary mixtures
drug:excipient which underwent the same treatment. The purpose is to find indications of interactions within the mixtures,
which means a potential incompatibility of the excipient. Both morphological and thermal properties are sensitive to interactions
which leave mostly unmodified the IR spectra and the X-rays patterns. In particular, we find that indomethacin does interact
with PVP and MGST, but is certainly compatible with Avicel©.
Manuscript Submission: HERE
For subscription options, please visit the website of Springer.
Copyright Akadémiai Kiadó
AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Character limit 500/500