Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 73: Issue 2
The effect of storage on the behaviour of Eudragit NE free film
Authors:
J. Bajdik University of Szeged Department of Pharmaceutical Technology Eötvös str. 6 H-6720 Szeged Hungary Eötvös str. 6 H-6720 Szeged Hungary

Search for other papers by J. Bajdik in
Current site
Google Scholar
PubMed Close
,
K. Pintye-Hódi University of Szeged Department of Pharmaceutical Technology Eötvös str. 6 H-6720 Szeged Hungary Eötvös str. 6 H-6720 Szeged Hungary

Search for other papers by K. Pintye-Hódi in
Current site
Google Scholar
PubMed Close
,
G. Regdon University of Szeged Department of Pharmaceutical Technology H-6720 Szeged Eötvös. u. 6 Hungary H-6720 Szeged Eötvös. u. 6 Hungary

Search for other papers by G. Regdon in
Current site
Google Scholar
PubMed Close
,
P. Fazekas Egis Pharmaceuticals, Lacta Factory P.O. Box 54 H-9901 Körmend Hungary P.O. Box 54 H-9901 Körmend Hungary

Search for other papers by P. Fazekas in
Current site
Google Scholar
PubMed Close
,
P. Szabó-Révész University of Szeged Department of Pharmaceutical Technology H-6720 Szeged Eötvös. u. 6 Hungary H-6720 Szeged Eötvös. u. 6 Hungary

Search for other papers by P. Szabó-Révész in
Current site
Google Scholar
PubMed Close
, and
I. Erős University of Szeged Department of Pharmaceutical Technology H-6720 Szeged Eötvös. u. 6 Hungary H-6720 Szeged Eötvös. u. 6 Hungary

Search for other papers by I. Erős in
Current site
Google Scholar
PubMed Close
Pages:
607–613
Online Publication Date:
31 Oct 2004
Publication Date:
01 Aug 2003
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1025438415304
Keywords:
Eudragit NE 30 D; crystallisation; nonoxynol 100; storage; film thickness
Restricted access

Abstract  

Eudragit NE 30 D aqueous dispersion is a commonly used coating material, which contains methacrylate copolymers as film-forming agent and nonoxynol 100 as an endogenous emulsifier. The dissolution of the active ingredient from Eudragit NE-coated samples during storage is known to undergo a change. The crystallization of the emulsifier agent can play an important role in this. This polymer is not soluble in the gastrointestinal tract, but is permeable. Various parameters can influence the permeability of this film, e.g. via the tensile properties of the film. Change in the film thickness can cause the stretching of the film on a solid surface. Alterations in this physical parameter of the film were measured and the effects of different storage conditions were evaluated. The free film was prepared by spraying onto teflon. The crystallization of nonoxynol was followed via the changes in the DSC curve of the free film. A relationship was found between the film thickness and the crystallization of nonoxynol. It was established that the different storage conditions influence these changes. The temperature and the air humidity are important in this phenomenon. Lengthening of the storage time increased the difference in film thickness and crystallisation of emulsifier.

  • Collapse
  • Expand
Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Oct 2024 34 0 0
Nov 2024 12 0 0
Dec 2024 9 0 0
Jan 2025 14 0 0
Feb 2025 16 0 0
Mar 2025 5 0 0
Apr 2025 0 0 0