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  • 1 University of Szeged Department of Pharmaceutical Technology Eötvös str. 6 H-6720 Szeged Hungary Eötvös str. 6 H-6720 Szeged Hungary
  • | 2 University of Szeged Department of Pharmaceutical Technology H-6720 Szeged Eötvös. u. 6 Hungary H-6720 Szeged Eötvös. u. 6 Hungary
  • | 3 Egis Pharmaceuticals, Lacta Factory P.O. Box 54 H-9901 Körmend Hungary P.O. Box 54 H-9901 Körmend Hungary
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Abstract  

Eudragit NE 30 D aqueous dispersion is a commonly used coating material, which contains methacrylate copolymers as film-forming agent and nonoxynol 100 as an endogenous emulsifier. The dissolution of the active ingredient from Eudragit NE-coated samples during storage is known to undergo a change. The crystallization of the emulsifier agent can play an important role in this. This polymer is not soluble in the gastrointestinal tract, but is permeable. Various parameters can influence the permeability of this film, e.g. via the tensile properties of the film. Change in the film thickness can cause the stretching of the film on a solid surface. Alterations in this physical parameter of the film were measured and the effects of different storage conditions were evaluated. The free film was prepared by spraying onto teflon. The crystallization of nonoxynol was followed via the changes in the DSC curve of the free film. A relationship was found between the film thickness and the crystallization of nonoxynol. It was established that the different storage conditions influence these changes. The temperature and the air humidity are important in this phenomenon. Lengthening of the storage time increased the difference in film thickness and crystallisation of emulsifier.

Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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