Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 73: Issue 2
Study of thermal behaviour of sugar alcohols
Authors:
Á. Gombás University of Szeged Department of Pharmaceutical Technology H-6720 Szeged Eötvös. u. 6 Hungary H-6720 Szeged Eötvös. u. 6 Hungary

Search for other papers by Á. Gombás in
Current site
Google Scholar
PubMed Close
,
P. Szabó-Révész University of Szeged Department of Pharmaceutical Technology H-6720 Szeged Eötvös. u. 6 Hungary H-6720 Szeged Eötvös. u. 6 Hungary

Search for other papers by P. Szabó-Révész in
Current site
Google Scholar
PubMed Close
,
G. Regdon University of Szeged Department of Pharmaceutical Technology H-6720 Szeged Eötvös. u. 6 Hungary H-6720 Szeged Eötvös. u. 6 Hungary

Search for other papers by G. Regdon in
Current site
Google Scholar
PubMed Close
, and
I. Erős University of Szeged Department of Pharmaceutical Technology H-6720 Szeged Eötvös. u. 6 Hungary H-6720 Szeged Eötvös. u. 6 Hungary

Search for other papers by I. Erős in
Current site
Google Scholar
PubMed Close
Pages:
615–621
Online Publication Date:
31 Oct 2004
Publication Date:
01 Aug 2003
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1025490432142
Keywords:
mannitol; crushing strength; sorbitol; glass transition; X-ray powder diffraction
Restricted access

Abstract  

Mannitol and sorbitol are widely used in the pharmaceutical and food industry. There are some technological procedures such as spray-drying, freeze-drying, tablet compression, during which there is a possibility of heat effect. The purpose of this work was to study the thermal properties of sorbitol, mannitol and their mixtures. Furthermore, these materials and their tablet pressing were studied after melting and solidification. The results of the study prove that the use of sorbitol or mannitol alone is disadvantageous in melt technology. The use of mannitol is limited because of its high melting point (165C) and the polymorph transition after melting. Sorbitol (melting point: 96.8C) vitrifies from melt, therefore it is hard to handle during further processing. The melting point of the eutectic mixture (1.8% mannitol and 98.2% sorbitol) was 93.6C. This mixture was unsuited for pressing because of its glassy property. Our results showed that the most favourable composition was the mixture of 30% mannitol and 70% sorbitol (melting point: 131.8C) for tablet formulation. This mixture can be recommended for the formulation of such lozenge and hard candy tablets, where the active ingredient decomposes at higher temperature (>131.8C).

  • Collapse
  • Expand
Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Nov 2024 17 0 0
Dec 2024 21 0 0
Jan 2025 21 0 0
Feb 2025 24 0 0
Mar 2025 17 2 2
Apr 2025 8 0 0
May 2025 4 0 0