Inclusion complexation between cyclodextrin derivatives (hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin) and a very
poorly water-soluble antifungal agent, ketoconazole, was studied. Solid products were prepared by physical mixing, kneading
and spray-drying methods in four molecular ratios: 2:1, 1:1, 1:2 and 1:3. The possibility of complex formation between the
drug and the cyclodextrins was studied by thermal analysis. Supplementary techniques, such as X-ray diffractometry and Fourier
transformation-infrared spectroscopy, were also applied to interpret the results of the thermal study of the products.