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  • 1 University of Ege Department of Pharmaceutical Technology, Faculty of Pharmacy 35100 Izmir Turkey 35100 Izmir Turkey
  • | 2 University of Szeged Department of Pharmaceutical Technology 6720 Szeged Eötvös u. 6 Hungary 6720 Szeged Eötvös u. 6 Hungary
  • | 3 University of Szeged Department of Physical Chemistry 6720 Szeged Rerrich Béla tér 1 Hungary 6720 Szeged Rerrich Béla tér 1 Hungary
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Abstract  

Inclusion complexation between cyclodextrin derivatives (hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin) and a very poorly water-soluble antifungal agent, ketoconazole, was studied. Solid products were prepared by physical mixing, kneading and spray-drying methods in four molecular ratios: 2:1, 1:1, 1:2 and 1:3. The possibility of complex formation between the drug and the cyclodextrins was studied by thermal analysis. Supplementary techniques, such as X-ray diffractometry and Fourier transformation-infrared spectroscopy, were also applied to interpret the results of the thermal study of the products.