A method has been developed that utilizes a special custom-made mixing device and HPLC micro liter syringe to perform mixing
experiments of liquid systems directly in open measuring cells of differential scanning calorimeters. The present paper describes
how to determine mixing enthalpies from time scans of the isothermal heat flux during an exothermal or endothermal process.
Using ethylene glycol and the slightly volatile component water to calibrate the mixing calorimeter, the mixing enthalpy of
the binary system poly(ethylene glycol) 400/water could be determined with sufficient precision compared to the results of
measurements with a conventional flow calorimeter.